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| Nomenclature |
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Symbol:
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Tg(Il1rn)1Dih
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Name:
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transgene insertion 1, David Hirsh
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MGI ID: |
MGI:3573755 |
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Synonyms: |
IL-1ratg, IL1ra Tg |
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Transgene:
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Tg(Il1rn)1Dih
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x CBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains the sequence encoding the secreted gene protein and approximately 2.0kb of upstream and 2.5kb of downstream untranslated flanking regions, and a site directed mutation (G to A) in exon 3. Northern blot analysis of liver tissue following LPS challenge detects overexpression. Two lines were created and called T14 and T16. (J:36387)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:36387
Hirsch E et al.,
"Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice."
Proc Natl Acad Sci U S A 1996 Oct 1;93(20):11008-13
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All: |
5 reference(s)
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Analysis Tools
