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| Nomenclature |
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Symbol:
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Nbntm2Nus
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Name:
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nibrin;
targeted mutation 2, Andre Nussenzweig
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MGI ID: |
MGI:3531643 |
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Synonyms: |
Nbs1loxP |
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Gene:
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Nbn
Location:
Chr4:15957925-15992589 bp, + strand
Genetic Position: Chr4,
6.66 cM, cytoband A
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:96102
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette flanked by loxP sites was introduced into intron 1. A third loxP site was inserted into upstream of exon 1. (J:96102)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nbn Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:96102
Reina-San-Martin B et al.,
"Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1."
Proc Natl Acad Sci U S A 2005 Feb 1;102(5):1590-5
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All: |
5 reference(s)
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Analysis Tools
