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| Nomenclature |
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Symbol:
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Dmdtm1.1Khan
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Name:
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dystrophin, muscular dystrophy;
targeted mutation 1.1, Kazunori Hanaoka
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MGI ID: |
MGI:3531484 |
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Gene:
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Dmd
Location:
ChrX:82948870-85206141 bp, + strand
Genetic Position: ChrX,
38.38 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:96210
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Parent Cell Line:
| TT2F (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele was produced from Dmdtm1Khan. The entire 2.4 Mb Dmd gene was removed by transient expression of cre recombinase in correctly targeted ES cells. RT-PCR and Western blot analyses failed to detect any expressions of full-length and short isoforms in muscle, cerebrum, and cerebellum. (J:96210)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:96210
Kudoh H et al.,
"A new model mouse for Duchenne muscular dystrophy produced by 2.4Mb deletion of dystrophin gene using Cre-loxP recombination system."
Biochem Biophys Res Commun 2005 Mar 11;328(2):507-16
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All: |
2 reference(s)
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Analysis Tools
