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| Nomenclature |
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Symbol:
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Sprtm1Lex
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Name:
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sepiapterin reductase;
targeted mutation 1, Lexicon Genetics
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MGI ID: |
MGI:3528977 |
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Gene:
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Spr
Location:
Chr6:85133678-85137766 bp, - strand
Genetic Position: Chr6,
37.15 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:131376
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 and 2 were replaced with a lacZ-neo cassette. The absence of protein product was confirmed by western blot analysis on liver and kidney extracts. (J:131376)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Spr Mutation:
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1 strain or line available |
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| References |
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Original: |
J:131376
Takazawa C et al.,
"A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease."
Biochem Biophys Res Commun 2008 Mar 21;367(4):787-92
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All: |
2 reference(s)
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Analysis Tools
