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| Nomenclature |
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Symbol:
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Tg(PDGFB-SNCA)4Ema
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Name:
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transgene insertion 4, Eliezer Masliah
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MGI ID: |
MGI:3528873 |
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Synonyms: |
line D, PDGFbeta-alpha-syn |
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Transgene:
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Tg(PDGFB-SNCA)4Ema
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains human platelet derived growth factor, B polypeptide (PDGFB) promoter, an SV40 splice site, 423 bp of human cDNA encoding full length wild-type alpha synuclein (SNCA), and SV40 polyadenylation sequences.
(J:60638)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
This line, which showed the highest transgene expression levels, was originally designated line D. Line C, which showed the lowest transgene expression levels, and lines A, B, and M were also generated.
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| References |
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Original: |
J:60638
Masliah E et al.,
"Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders."
Science 2000 Feb 18;287(5456):1265-9
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All: |
17 reference(s)
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Analysis Tools
