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| Nomenclature |
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Symbol:
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Dok1tm1Ppp
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Name:
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docking protein 1;
targeted mutation 1, Pier Paolo Pandolfi
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MGI ID: |
MGI:3527270 |
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Synonyms: |
p62dok- |
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Gene:
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Dok1
Location:
Chr6:83030934-83033471 bp, - strand
Genetic Position: Chr6,
35.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:95640
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette was used to replace exons 1 through 4 and part of exon 5. Western blot analysis of spleen and thymus did not detect protein gene product. (J:95640)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Dok1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:95640
Di Cristofano A et al.,
"p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)."
J Exp Med 2001 Aug 6;194(3):275-84
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All: |
5 reference(s)
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Analysis Tools
