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| Nomenclature |
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Symbol:
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Agrptm2(DTR)Rpa
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Name:
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agouti related protein;
targeted mutation 2, Richard D Palmiter
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MGI ID: |
MGI:3527177 |
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Synonyms: |
AgrpDTR |
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Gene:
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Agrp
Location:
Chr8:105566700-105568298 bp, - strand
Genetic Position: Chr8,
53.04 cM, cytoband D1-D2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:132360
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Parent Cell Line:
| AK7 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The human diphtheria toxin receptor followed by an IRES-DsRed2 reporter gene was targeted to the Agrp locus to allow conditional killing of these cells. Germ-line, cre-mediated recombination was used to remove the neo cassette. (J:132360)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Agrp Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:132360
Luquet S et al.,
"NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates."
Science 2005 Oct 28;310(5748):683-5
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All: |
7 reference(s)
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Analysis Tools
