|
|
| Nomenclature |
|
Symbol:
|
Tg(Igh-6/Igh-V125)2Jwt
|
|
Name:
|
transgene insertion 2, James W Thomas
|
|
MGI ID: |
MGI:3526723 |
|
Synonyms: |
125HC, 125Tg, 125VH, VH125, VH125Tg, VH Tg125 |
|
Transgene:
|
Tg(Igh-6/Igh-V125)2Jwt
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
(C57BL/6 x DBA/2)F1
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: This construct encodes an IgMa constant region with the variable specificity from BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125 that was the source of the immunoglobulin heavy chain VDJ sequence in this transgene. The resulting antibody binds insulin when co-expressed with a transgene encoding the light chain with the VJ of mAB125. (J:91866)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:91866
Rojas M et al.,
"Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen."
J Immunol 2001 Mar 1;166(5):3194-200
|
|
All: |
5 reference(s)
|
|
Analysis Tools
