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| Nomenclature |
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Symbol:
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Rsc1a1tm1Koep
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Name:
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regulatory solute carrier protein, family 1, member 1;
targeted mutation 1, Hermann Koepsell
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MGI ID: |
MGI:3526519 |
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Synonyms: |
RS1- |
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Gene:
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Rsc1a1
Location:
Chr4:141683851-141685599 bp, - strand
Genetic Position: Chr4,
74.7 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:95148
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The coding region was replaced by a neomycin selection cassette in reverse orientation. Northern blot of kidney samples from mutants demonstrated the absence of wild-type mRNA. Western blot indicated the absence of protein in mutant kidney and intestine. (J:95148)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rsc1a1 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:95148
Osswald C et al.,
"Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity."
Mol Cell Biol 2005 Jan;25(1):78-87
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All: |
1 reference(s)
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Analysis Tools
