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| Nomenclature |
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Symbol:
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Spred1tm1Hiin
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Name:
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sprouty protein with EVH-1 domain 1, related sequence;
targeted mutation 1, Hiromasa Inoue
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MGI ID: |
MGI:3526452 |
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Synonyms: |
Spred-1- |
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Gene:
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Spred1
Location:
Chr2:117121374-117182279 bp, + strand
Genetic Position: Chr2,
59.03 cM, cytoband E5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:95263
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neo cassette replaced much of exon 4, including the sequence encoding the kit-binding domain and Sprouty-related COOH-terminal cystein-rich domains. RT-PCR confirmed the lack of transcript in mutant brain samples, and Western blot showed the lack of protein in mutant brain, liver, and kidney samples. (J:95263)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Spred1 Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:95263
Inoue H et al.,
"Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness."
J Exp Med 2005 Jan 3;201(1):73-82
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All: |
3 reference(s)
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Analysis Tools
