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| Nomenclature |
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Symbol:
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Ctsgtm2.1(PML/RARA)Ley
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Name:
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cathepsin G;
targeted mutation 2.1, Timothy J Ley
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MGI ID: |
MGI:3526413 |
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Synonyms: |
Ctsgtm2.1Ley, mCGPML-RARalpha, mCGPR(deltaPGK-neo), PRWT |
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Gene:
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Ctsg
Location:
Chr14:56099881-56102574 bp, - strand
Genetic Position: Chr14,
28.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84230
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A human cDNA encoding the PML-RARalpha fusion and a loxP flanked PGK-neo was inserted into the 5' UTR. Transient Cre expression removed the floxed PGK-neo. (J:84230)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ctsg Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:84230
Westervelt P et al.,
"High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression."
Blood 2003 Sep 1;102(5):1857-65
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All: |
13 reference(s)
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Analysis Tools
