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| Nomenclature |
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Symbol:
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Agxttm1Ull
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Name:
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alanine-glyoxylate aminotransferase;
targeted mutation 1, Eduardo C Salido
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MGI ID: |
MGI:3526219 |
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Synonyms: |
AgtKO |
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Gene:
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Agxt
Location:
Chr1:93135276-93145421 bp, + strand
Genetic Position: Chr1,
47.0 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:117145
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Parent Cell Line:
| JM-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene was used to replace exons 4-8 of the locus. Absence of protein was confirmed by Western blot analysis. (J:117145)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Agxt Mutation:
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1 strain or line available |
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| References |
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Original: |
J:117145
Salido EC et al.,
"Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer."
Proc Natl Acad Sci U S A 2006 Nov 28;103(48):18249-54
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All: |
4 reference(s)
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Analysis Tools
