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| Nomenclature |
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Symbol:
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Erbb2tm8(Erbb2)Mul
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Name:
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v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian);
targeted mutation 8, William J Muller
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MGI ID: |
MGI:3525444 |
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Synonyms: |
ErbB2KI, Flneo NeuNT, NeuNT, neuNTki |
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Gene:
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Erbb2
Location:
Chr11:98412470-98437716 bp, + strand
Genetic Position: Chr11,
61.75 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61202
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 of the endogenous Erbb2 allele was replaced by a lox-P flanked PGK-neomycin-HSV polyA cassette, followed by an oncogenic Erbb2 cDNA containing an activating point mutation in the transmembrane domain. (J:61202)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Erbb2 Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:61202
Andrechek ER et al.,
"Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis."
Proc Natl Acad Sci U S A 2000 Mar 28;97(7):3444-9
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All: |
11 reference(s)
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Analysis Tools
