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| Nomenclature |
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Symbol:
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Wisp3tm1Mawa
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Name:
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WNT1 inducible signaling pathway protein 3;
targeted mutation 1, Matthew L Warman
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MGI ID: |
MGI:3525361 |
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Synonyms: |
Wisp3- |
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Gene:
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Wisp3
Location:
Chr10:39150971-39163794 bp, - strand
Genetic Position: Chr10,
20.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94500
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A lacZ-neo was inserted to the 3' end of exon 3. The allele resulted in a fusion protein that has Beta-gal activity under the endogenous promoter. The Wisp3 protein is truncated immediately after the IGFBP domain, and lacks the vWF, TSP and C-terminal domains. RT-PCR of cartilage from mutants showed a lack of wild-type transcript. Beta-gal activity was confirmed in cells transfected with a vector expressing the Wisp3-lacZ fusion protein. (J:94500)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Wisp3 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:94500
Kutz WE et al.,
"WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice."
Mol Cell Biol 2005 Jan;25(1):414-21
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All: |
1 reference(s)
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Analysis Tools
