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| Nomenclature |
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Symbol:
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Nfkbiztm1Mamo
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Name:
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nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta;
targeted mutation 1, Masami Morimatsu
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MGI ID: |
MGI:3525252 |
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Synonyms: |
MAIL- |
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Gene:
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Nfkbiz
Location:
Chr16:55811375-55838899 bp, - strand
Genetic Position: Chr16,
33.65 cM, cytoband C1.2 - C1.3
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Allergic dermatitis in Nfkbiztm1Mamo/Nfkbiztm1Mamo mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:95040
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A targeting vector was used to replace most of exon 4 and all of exons 5-8, the coding sequence for part of the ankyrin repeats I and II, with a neo and to insert a nonsense mutation just downstream of the start codon. (J:95040)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nfkbiz Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:95040
Shiina T et al.,
"Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease."
J Biol Chem 2004 Dec 31;279(53):55493-8
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All: |
2 reference(s)
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Analysis Tools
