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| Nomenclature |
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Symbol:
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Ambntm1Nid
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Name:
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ameloblastin;
targeted mutation 1, Yoshihiko Yamada
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MGI ID: |
MGI:3525231 |
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Synonyms: |
Ambn- |
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Gene:
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Ambn
Location:
Chr5:88456011-88468527 bp, + strand
Genetic Position: Chr5,
43.63 cM
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Defects in enamel formation of Ambntm1Nid/Ambntm1Nid mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94844
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neo replaced a genomic fragment extending from the XbaI site at Chr5:88889874 (Build 37) in intron 4 to the EcoRI site at Chr5:88893057 in intron 6. Both exons 5 and 6 are thus deleted. Neither transcript nor protein was detected in mutant mice. (Additional information provided by authors.) (J:94844)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ambn Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:94844
Fukumoto S et al.,
"Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts."
J Cell Biol 2004 Dec 6;167(5):973-83
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All: |
4 reference(s)
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Analysis Tools
