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| Nomenclature |
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Symbol:
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Tg(CAG-WRN*K577M)5025Wcl
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Name:
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transgene insertion 5025, Warren C Ladiges
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MGI ID: |
MGI:3525073 |
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Synonyms: |
K577-WRN, Tg(ACTB-WRN*K577M)5025Wcl, Tg(CAG-WRN*K577M)5025Wcl |
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Transgene:
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Tg(CAG-WRN*K577M)5025Wcl
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x C3H
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene is composed of a full length cDNA encoding human WRN with a mutation that alters lysine 577 to methionine expressed under the control of a cytomegalovirus enhancer and a chicken beta-actin promoter, and was followed by a rabbit beta-globin polyadenylation site. (J:95127)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This line is representative of three lines made, which include the 4128, 4998 and the 5025 lines.
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| References |
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Original: |
J:95127
Wang L et al.,
"Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene."
Genetics 2000 Jan;154(1):357-62
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All: |
2 reference(s)
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Analysis Tools
