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| Nomenclature |
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Symbol:
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Dctn1tm1Cai
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Name:
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dynactin 1;
targeted mutation 1, Huaibin Cai
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MGI ID: |
MGI:3522484 |
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Synonyms: |
Dctn1m |
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Gene:
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Dctn1
Location:
Chr6:83165920-83200117 bp, + strand
Genetic Position: Chr6,
35.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:129269
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Nucleotide substitutions (GGGC to CTGA) in exon 2 introduced an amino acid substitution of a serine for a glycine at position 59 (G59S). A loxP site was inserted into intron 1 and a floxed neo cassette was also inserted into intron 3 and subsequently removed by cre-mediated recombination. (J:129269)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Dctn1 Mutation:
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20 strains or lines available |
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| References |
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Original: |
J:129269
Lai C et al.,
"The G59S mutation in p150(glued) causes dysfunction of dynactin in mice."
J Neurosci 2007 Dec 19;27(51):13982-90
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All: |
1 reference(s)
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Analysis Tools
