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| Nomenclature |
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Symbol:
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Cdh2tm1Glr
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Name:
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cadherin 2;
targeted mutation 1, Glenn L Radice
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MGI ID: |
MGI:3522469 |
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Synonyms: |
N-cadflox |
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Gene:
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Cdh2
Location:
Chr18:16588877-16809246 bp, - strand
Genetic Position: Chr18,
10.1 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:98828
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Exon 1, which contains the translational start site and upstream transcriptional regulatory sequences, was flanked with loxP sites. An FRT-flanked neomycin selection cassette was inserted into intron 1 and subsequently removed by crossing with mice expressing FLP recombinase in the germline. (J:98828)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:98828
Kostetskii I et al.,
"Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure."
Circ Res 2005 Feb 18;96(3):346-54
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All: |
19 reference(s)
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Analysis Tools
