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| Nomenclature |
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Symbol:
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Npbwr1tm1Rck
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Name:
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neuropeptides B/W receptor 1;
targeted mutation 1 Jeffrey M Friedman
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MGI ID: |
MGI:3522352 |
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Synonyms: |
Gpr7- |
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Gene:
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Npbwr1
Location:
Chr1:5913707-5917398 bp, - strand
Genetic Position: Chr1,
1.89 cM, cytoband A1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94820
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129P/Ola
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: An IRES-tau-EGFP cassette was inserted into the single coding exon. Northern blot of mutant hypothalamus showed the presence of a transcript increased by 6 kb compared to wild-type, confirming the insertion of the cassette. (J:94820)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Npbwr1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:94820
Ishii M et al.,
"Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity."
Proc Natl Acad Sci U S A 2003 Sep 2;100(18):10540-5
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All: |
2 reference(s)
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Analysis Tools
