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| Nomenclature |
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Symbol:
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Npr2tm1Gar
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Name:
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natriuretic peptide receptor 2;
targeted mutation 1, David L Garbers
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MGI ID: |
MGI:3522129 |
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Synonyms: |
Npr2- |
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Gene:
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Npr2
Location:
Chr4:43631935-43651244 bp, + strand
Genetic Position: Chr4,
23.05 cM
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Skeletal comparison of wild type and Npr2tm1Gar/Npr2tm1Gar mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94718
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 3-7, which encode the C-terminal half of the extracellular ligand-binding domain and the transmembrane segment, were replaced with a neo. mRNA was not detected in brains of mutant animals. (J:94718)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:94718
Tamura N et al.,
"Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs."
Proc Natl Acad Sci U S A 2004 Dec 7;101(49):17300-5
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All: |
1 reference(s)
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Analysis Tools
