|
|
| Nomenclature |
|
Symbol:
|
Irf6Gt(OST398253)Lex
|
|
Name:
|
interferon regulatory factor 6;
gene trap OST398253, Lexicon Genetics
|
|
MGI ID: |
MGI:3522096 |
|
Synonyms: |
Irf6gt1, Irf6Gt(VICTR48)1Bcsl |
|
Gene:
|
Irf6
Location:
Chr1:193153112-193172042 bp, + strand
Genetic Position: Chr1,
97.6 cM
|
|
Mutation
origin |
|
Mutant Cell Line:
| OST398253 (Lexicon Genetics) |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:94918
|
|
Parent Cell Line:
| Lex-1 (ES Cell) |
|
Strain of Origin:
|
129S5/SvEvBrd
|
|
Mutation
description |
|
Allele
Type: | |
Gene trapped |
|
Mutation: | |
Insertion of gene trap vector |
| |
|
Mutation details: The gene trap vector VICTR48 inserted into intron 1, 36 bp from the splice donor site. The vector contained flanking long terminal repeats, splice acceptor and donor sites, the ORF for neo, stop codons, polyA signal, the PGK promoter, marker fusion transcript and OmniBank sequence tag fusion transcript. Protein was not detected in mutants by Western blot. (J:46940)
|
|
Sequence Tags: |
|
Sequence tag details (1 tag)
| Tag ID | GenBank ID | Method |
Tag Location (trapped strand)* | Select |
* GRCh37.p10
(strand of gene trap mutagenesis) |
|
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
This mutation is present in Lexicon Genomics' gene trap-mutated ES cell line OST398253. It was generated in an unspecified 129/Sv-derived ES cell line by random insertion of the VICTR48 gene trap vector.
|
| References |
|
Original: |
J:94918
Schutte B et al.,
"Mice that lack Irf6 exhibit skin, limb and craniofacial abnormalities"
MGI Direct Data Submission 2005;():
|
|
All: |
7 reference(s)
|
|
Analysis Tools
