|
|
| Nomenclature |
|
Symbol:
|
Serpini2pq
|
|
Name:
|
serine (or cysteine) peptidase inhibitor, clade I, member 2;
pequeno
|
|
MGI ID: |
MGI:3521922 |
|
Gene:
|
Serpini2
Location:
Chr3:75242370-75270078 bp, - strand
Genetic Position: Chr3,
33.74 cM
|
|
Runted size and acinar cell loss in Serpini2pq/Serpini2pq mice
Show the 2 image(s) involving this allele.
|
 |
|
Transgene
origin |
|
Strain of Origin:
|
C57BL/6J
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, gene disruption) |
|
Mutation: | |
Intergenic deletion |
| |
|
Mutation details: Random transgene insertion leading to an approximately 210-kb deletion which includes the entire Serpini2 gene and several 3' exons of Ensembl-predicted novel gene transcript sequences ENSMUST00000062199.1 and ENSMUST00000038943.1. BAC transgene complementation demonstrated that Serpini2 deletion is responsible for the phenotype. (J:115744)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Serpini2 Mutation:
|
1 strain or line available |
|
| References |
|
Original: |
J:115744
Loftus SK et al.,
"Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency."
PLoS Genet 2005 Sep;1(3):e38
|
|
All: |
1 reference(s)
|
|
Analysis Tools
