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| Nomenclature |
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Symbol:
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Tg(KRT14-HPV16E7)2304Plam
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Name:
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transgene insertion 2304, Paul F Lambert
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MGI ID: |
MGI:3514313 |
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Synonyms: |
2304, K14E7, K14-E7, K14HPV16E7 |
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Transgene:
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Tg(KRT14-HPV16E7)2304Plam
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains a HPV16 fragment (nt79-883) encompassing both the E6 and E7 genes along with promoter, 3'UTR and polyA sequences from human KRT14. Only E7 is expressed due to the presence of a translation termination linker in the N terminal region of the E6 gene. Transgene expression is targeted toward epithelial tissues. Mice derived from founder 2304 had 2 copies of the transgene. Mice derived from founder 2332 had 7-8 copies of the transgene. this is a representative record for lines 2304 and 2332 which have identical phenotypes. (J:86018)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:86018
Herber R et al.,
"Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene."
J Virol 1996 Mar;70(3):1873-81
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All: |
24 reference(s)
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Analysis Tools
