Notch1tm3(cre)Rko
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Notch1tm3(cre)Rko
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Name:
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notch 1;
targeted mutation 3, Raphael Kopan
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MGI ID: |
MGI:3514150 |
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Synonyms: |
N1::cre, N1::creLO, N1::cretg, N1IP-Cre, N1IP::CRELOW, NIP-Cre |
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Gene:
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Notch1
Location:
Chr2:26457903-26516663 bp, - strand
Genetic Position: Chr2,
18.91 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:119910
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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The intracellular domain was replaced with cre recombinase. (J:119910)
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Recombinase activity
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Activity in:
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alimentary system,
cardiovascular system,
embryo-other,
endocrine system,
extraembryonic component,
integumental system,
limbs,
mesenchyme,
nervous system,
renal & urinary system,
sensory organs
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Not detected in:
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hemolymphoid system,
muscle
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Driver:
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Notch1
Summary of all recombinase alleles
driven by Notch1.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:119910
Vooijs M et al.,
"Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE."
Development 2007 Feb;134(3):535-44
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All: |
4 reference(s)
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Analysis Tools
