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| Nomenclature |
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Symbol:
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Abcg8tm1Elk
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Name:
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ATP-binding cassette, sub-family G (WHITE), member 8;
targeted mutation 1, Eric L Klett
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MGI ID: |
MGI:3514037 |
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Synonyms: |
Abcg8-, Abcg8/sterolin2 |
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Gene:
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Abcg8
Location:
Chr17:84676302-84700333 bp, + strand
Genetic Position: Chr17,
55.02 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94759
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Part of exon 3 through part of exon 4 was replaced by a neomycin resistance cassette resulting in disruption of the ABC Walker A motif. No transcription was detected by Northern blot analysis. (J:94759)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:94759
Klett EL et al.,
"A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol."
BMC Med 2004 Mar 24;2(1):5
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All: |
8 reference(s)
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Analysis Tools
