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| Nomenclature |
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Symbol:
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Prg4tm1Mawa
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Name:
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proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein);
targeted mutation 1, Matthew Warman
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MGI ID: |
MGI:3513195 |
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Synonyms: |
Prg4- |
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Gene:
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Prg4
Location:
Chr1:150449816-150466165 bp, - strand
Genetic Position: Chr1,
63.84 cM, cytoband G
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Prg4tm1Mawa/Prg4tm1Mawa mice develop joint disease with increasing age
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:96756
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The targeting construct was designed to create a Prg4-B-gal fusion protein by substituting lacZ for exon 6. Northern blot and in situ hybridization, however, detected no transcript in livers of mutant mice. RT-PCR of synovial and liver mRNA showed aberrant mRNA splicing from the allele which was thought to create a nonsense mediated mRNA decay. (J:96756)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Prg4 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:96756
Rhee DK et al.,
"The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth."
J Clin Invest 2005 Mar;115(3):622-31
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All: |
6 reference(s)
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Analysis Tools
