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| Nomenclature |
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Symbol:
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Slc12a3tm1Ges
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Name:
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solute carrier family 12, member 3;
targeted mutation 1, Gary E Shull
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MGI ID: |
MGI:3513101 |
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Synonyms: |
Ncc- |
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Gene:
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Slc12a3
Location:
Chr8:94329208-94366222 bp, + strand
Genetic Position: Chr8,
46.46 cM
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Mitochondrial abnormalities in renal distal convoluted tubule cells of Slc12a3tm1Ges/Slc12a3tm1Ges mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50596
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin gene was inserted into exon 12. Kidneys from mutants demonstrated a lack of transcript by Northern blot analysis. (J:50596)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:50596
Schultheis PJ et al.,
"Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule."
J Biol Chem 1998 Oct 30;273(44):29150-5
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All: |
8 reference(s)
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Analysis Tools
