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| Nomenclature |
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Symbol:
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Lgr5tm1Ah
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Name:
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leucine rich repeat containing G protein coupled receptor 5;
targeted mutation 1, Aaron Hsueh
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MGI ID: |
MGI:3512420 |
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Synonyms: |
LGR5-, Lgr5-lacZ, Lgr5tm1Lex |
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Gene:
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Lgr5
Location:
Chr10:115450311-115587780 bp, - strand
Genetic Position: Chr10,
63.51 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94196
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Parent Cell Line:
| Lex-1 (ES Cell) |
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Strain of Origin:
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129S5/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 18, encoding the seven-transmembrane region plus the C-terminal tail, was replaced with a LacZ-neo cassette via homologous recombination. (J:94196)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lgr5 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:94196
Morita H et al.,
"Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension."
Mol Cell Biol 2004 Nov;24(22):9736-43
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All: |
10 reference(s)
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Analysis Tools
