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| Nomenclature |
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Symbol:
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Fgf23tm1Blan
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Name:
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fibroblast growth factor 23;
targeted mutation 1, Beate Lanske
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MGI ID: |
MGI:3512143 |
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Synonyms: |
Fgf-23- |
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Gene:
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Fgf23
Location:
Chr6:127072902-127081408 bp, + strand
Genetic Position: Chr6,
61.92 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94041
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1-3 were replaced with lacZ and a neomycin resistance gene. LacZ was cloned in frame downstream of the endogenous initiator methionine. Staining of embryos indicates the mutant gene was expressed in heterozygotes. (J:94041)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgf23 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:94041
Sitara D et al.,
"Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice."
Matrix Biol 2004 Nov;23(7):421-32
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All: |
15 reference(s)
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Analysis Tools
