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| Nomenclature |
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Symbol:
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Bin1tm2Gcp
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Name:
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bridging integrator 1;
targeted mutation 2, George C Pendergast
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MGI ID: |
MGI:3512133 |
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Synonyms: |
Bin1flox |
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Gene:
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Bin1
Location:
Chr18:32377217-32435736 bp, + strand
Genetic Position: Chr18,
18.01 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:117330
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Parent Cell Line:
| IT2 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites flank exon 3. The 3' loxP site retained in the floxed ES cell line used to generate chimeric mouse includes a point mutant which reduces the efficiency of in vivo recombination ~50%. (J:117330)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:117330
Chang MY et al.,
"Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression."
Cancer Res 2007 Jan 1;67(1):100-7
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All: |
2 reference(s)
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Analysis Tools
