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| Nomenclature |
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Symbol:
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Ts(1716)65Dn
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Name:
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trisomy, Chr 16 translocation to Chr 17, Davisson 65
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MGI ID: |
MGI:3512067 |
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Synonyms: |
T(16C3-4;17A2)65Dn, Ts16, Ts65Dn |
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Gene:
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Ts(1716)65Dn
Location:
unknown
Genetic Position: Chr16,
Syntenic
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Mutation
origin |
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Mutation
description |
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Allele
Type: | |
Radiation induced |
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Mutation: | |
Translocation |
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Mutation details: About 15% of the distal end of chromosome 16 is fused to less than 10% of the centromeric end of chromosome 17 to form a small translocation chromosome. The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere. The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17. Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals. (J:30229, J:71031)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:30229
Davisson MT et al.,
"Segmental trisomy as a mouse model for Down syndrome."
Prog Clin Biol Res 1993;384():117-33
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All: |
168 reference(s)
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Analysis Tools
