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| Nomenclature |
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Symbol:
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Mc4rtm1Lowl
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Name:
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melanocortin 4 receptor;
targeted mutation 1, Bradford B Lowell
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MGI ID: |
MGI:3512050 |
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Synonyms: |
loxTB Mc4r |
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Gene:
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Mc4r
Location:
Chr18:66857715-66860472 bp, - strand
Genetic Position: Chr18,
39.72 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:115192
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP flanked PGK-neomycin selection marker inserted in the 5' UTR created a null allele. Cre recombinase deletes the selection marker, restoring normal activity of the allele. Mice fail to respond to MC4R agonist MTII. This is a null allele that can be "reactivated" by cre recombinase. (J:115192)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:115192
Balthasar N et al.,
"Divergence of melanocortin pathways in the control of food intake and energy expenditure."
Cell 2005 Nov 4;123(3):493-505
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All: |
12 reference(s)
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Analysis Tools
