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| Nomenclature |
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Symbol:
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Myo7aHdb
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Name:
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myosin VIIA;
headbanger
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MGI ID: |
MGI:3511858 |
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Synonyms: |
ABE6 |
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Gene:
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Myo7a
Location:
Chr7:98051060-98119524 bp, - strand
Genetic Position: Chr7,
53.57 cM
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Stereocilia defects in Myo7aHdb/Myo7a+ mice
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C3HeB/FeJ
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: An A to T transversion at position 531 in exon 6 of Myo7a was identified and is predicted to cause an isoleucine-to-phenylalanine amino acid substitution at position 178, however no evidence of complementation was found when homozygotes were mated with heterozygous Myo7a4626SB. (J:93998)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:93998
Rhodes CR et al.,
"A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment."
Mamm Genome 2004 Sep;15(9):686-97
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All: |
4 reference(s)
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Analysis Tools
