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| Nomenclature |
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Symbol:
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Ppargtm2Yba
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Name:
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peroxisome proliferator activated receptor gamma;
targeted mutation 2, Yaacob Barak
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MGI ID: |
MGI:3511358 |
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Synonyms: |
Ppargldi |
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Gene:
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Pparg
Location:
Chr6:115361221-115490401 bp, + strand
Genetic Position: Chr6,
53.41 cM, cytoband E3-F1
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Lipodystrophy phenotypes of Ppargtm2Yba/Pparg+ mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:125992
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 2 was replaced with an Idi cassette that contains an IRES-tTA, neo, poly-adenylation signal, TetO and flag-tagged cDNA. While expression is modest in adipose tissue, it is poor in the liver and placenta. (J:125992)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:125992
Kim S et al.,
"A mouse model of conditional lipodystrophy."
Proc Natl Acad Sci U S A 2007 Oct 16;104(42):16627-32
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All: |
2 reference(s)
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Analysis Tools
