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| Nomenclature |
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Symbol:
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Leprtm1Chua
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Name:
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leptin receptor;
targeted mutation 1, Streamson C Chua, Jr
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MGI ID: |
MGI:3511283 |
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Synonyms: |
Leprneo |
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Gene:
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Lepr
Location:
Chr4:101717404-101815352 bp, + strand
Genetic Position: Chr4,
46.96 cM
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Obesity in Leprtm1Chua/Leprtm1Chua mice (center) and normal weight in Leprtm1.1Chua/Leprtm1.1Chua (left)
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:94019
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP-frt-PGK-neo-frt cassette was inserted into intron 16 and a second loxP site was placed in exon 17. (J:94019)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lepr Mutation:
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27 strains or lines available |
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| References |
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Original: |
J:94019
McMinn JE et al.,
"An allelic series for the leptin receptor gene generated by CRE and FLP recombinase."
Mamm Genome 2004 Sep;15(9):677-85
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All: |
9 reference(s)
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Analysis Tools
