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| Nomenclature |
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Symbol:
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Tg(Myl2-FGF19)1Dfre
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Name:
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transgene insertion 1, Dorothy M French
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MGI ID: |
MGI:3510921 |
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Synonyms: |
FGF19, MLC-FGFG19 |
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Transgene:
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Tg(Myl2-FGF19)1Dfre
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The human FGF19 cDNA was ligated to a rat myosin light chain 2 promoter and followed by the splice donor/acceptor sites present between exons 4 and 5 of the human growth hormaone gene. RT-PCR analysis of skeletal muscle biopsies showed the presence of human transcript in transgenic mice. Transgenic protein was verified by enzyme-linked immunosorbent assay. This record is a representative transgene as founder lines were not named. (J:76323)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:76323
Tomlinson E et al.,
"Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity."
Endocrinology 2002 May;143(5):1741-7
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All: |
4 reference(s)
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Analysis Tools
