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| Nomenclature |
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Symbol:
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Zic1/Zic4tm1Kjmi
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Name:
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zinc finger protein of the cerebellum 1;
targeted mutation 1, Kathleen J Millen
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MGI ID: |
MGI:3510680 |
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Synonyms: |
Zic1-Zic4- |
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Gene:
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Zic1
Location:
Chr9:91358058-91365810 bp, - strand
Genetic Position: Chr9,
48.26 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:93955
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intergenic deletion |
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Mutation details: A targeting vector was designed to replace the 17.6 kb region between Zic1 and Zic4, as well as the coding region of the first exon of Zic4 and the entire first exon of Zic1. Transient Cre expression removed the neo in ES cells. (J:93955)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Zic1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:93955
Grinberg I et al.,
"Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation."
Nat Genet 2004 Oct;36(10):1053-5
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All: |
3 reference(s)
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Analysis Tools
