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| Nomenclature |
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Symbol:
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Pbx3tm1Mlc
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Name:
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pre B cell leukemia homeobox 3;
targeted mutation 1, Michael L Cleary
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MGI ID: |
MGI:3510441 |
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Synonyms: |
Pbx3- |
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Gene:
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Pbx3
Location:
Chr2:34171457-34373140 bp, - strand
Genetic Position: Chr2,
22.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:93761
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 3 was replaced with a neomycin resistance gene in opposite transcription orientation. The deletion created an early frame-shift mutation that caused termination of the reading frame upstream of its dimerization and DNA binding domains. Western blot indicated a lack of protein in brains of mutants. (J:93761)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pbx3 Mutation:
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11 strains or lines available |
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| References |
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Original: |
J:93761
Rhee JW et al.,
"Pbx3 deficiency results in central hypoventilation."
Am J Pathol 2004 Oct;165(4):1343-50
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All: |
6 reference(s)
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Analysis Tools
