|
|
| Nomenclature |
|
Symbol:
|
Tbx1tm1.1Dsr
|
|
Name:
|
T-box 1;
targeted mutation 1.1, Deepak Srivastava
|
|
MGI ID: |
MGI:3510040 |
|
Synonyms: |
Tbx1null |
|
Gene:
|
Tbx1
Location:
Chr16:18581713-18586969 bp, - strand
Genetic Position: Chr16,
11.51 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:93588
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
129/Sv
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Intragenic deletion |
| |
|
Mutation details: Crossing of Tbx1tm1Dsr with mice ubiquitously expressing Cre and mice expressing Flp recombinase in the germline creates this null allele in which the FRT-flanked neo and exons 4-8, which encode the T-box domain, were removed. (J:93588)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Tbx1 Mutation:
|
10 strains or lines available |
|
| References |
|
Original: |
J:93588
Hu T et al.,
"Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors."
Development 2004 Nov;131(21):5491-502
|
|
All: |
2 reference(s)
|
|
Analysis Tools
