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| Nomenclature |
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Symbol:
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Ido1tm1Alm
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Name:
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indoleamine 2,3-dioxygenase 1;
targeted mutation 1, Andrew L Mellor
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MGI ID: |
MGI:3505776 |
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Synonyms: |
IDO-, Ido1-, Ido1-KO |
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Gene:
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Ido1
Location:
Chr8:24584136-24597009 bp, - strand
Genetic Position: Chr8,
12.76 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:93796
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A Betagal and neomycin cassette replaced exons 3-5, which encode critical portions of the enzyme catalytic site. Also, a translation stop codon was introduced into exon 2. RT-PCR of total epididymis RNA from mutants showed no transcript was present. Western blot of mutant epididymis confirmed a lack of protein.
(J:93797)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:93796
Mellor AL et al.,
"Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion."
J Immunol 2003 Aug 15;171(4):1652-5
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All: |
39 reference(s)
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Analysis Tools
