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| Nomenclature |
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Symbol:
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Irs2tm2Mfw
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Name:
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insulin receptor substrate 2;
targeted mutation 2, Morris F White
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MGI ID: |
MGI:3497903 |
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Synonyms: |
fIrs2, Irs2L |
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Gene:
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Irs2
Location:
Chr8:10986961-11008430 bp, - strand
Genetic Position: Chr8,
5.35 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:93415
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed to flank the coding region with loxP sites. Transient expression of a Cre plasmid excised a floxed neo that had be included in the 5' region of the vector. (J:93415)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Irs2 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:93415
Lin X et al.,
"Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes."
J Clin Invest 2004 Nov;114(7):908-16
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All: |
12 reference(s)
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Analysis Tools
