|
|
| Nomenclature |
|
Symbol:
|
Rettm2(RET)Jmi
|
|
Name:
|
ret proto-oncogene;
targeted mutation 2, Jeffrey Milbrandt
|
|
MGI ID: |
MGI:3057332 |
|
Synonyms: |
Ret9, RetRET9 |
|
Gene:
|
Ret
Location:
Chr6:118151748-118197744 bp, - strand
Genetic Position: Chr6,
55.86 cM, cytoband E3-F1
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:93262
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
Not Specified
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Human RET9 cDNA and a floxed neo were inserted into exon 1 of the endogenous locus. Mating with mice expressing Cre in the germline excised the neo. RT-PCR showed expression of the mutant allele in brain. (J:93262)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Ret Mutation:
|
15 strains or lines available |
|
| References |
|
Original: |
J:93262
Jain S et al.,
"Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis."
Development 2004 Dec;131(21):5503-13
|
|
All: |
8 reference(s)
|
|
Analysis Tools
