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| Nomenclature |
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Symbol:
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Tg(GFAP-APOE_i3)37Hol
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Name:
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transgene insertion 37, David M Holtzman
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MGI ID: |
MGI:3057188 |
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Synonyms: |
GFAP-apoE3 line 37, Tg(GFAP-APOE*3)37Hol, Tg(GFAP-APOE3)37Hol |
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Transgene:
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Tg(GFAP-APOE_i3)37Hol
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 and CBA
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains sequence encoding human apolipoprotein E3 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Two lines were created (lines 2 and 37) with line 37 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. (J:93487)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:93487
Sun Y et al.,
"Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins."
J Neurosci 1998 May 1;18(9):3261-72
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All: |
13 reference(s)
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Analysis Tools
