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| Nomenclature |
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Symbol:
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Tg(TcraAI4)1Dvs
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Name:
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transgene insertion 1, David V Serreze
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MGI ID: |
MGI:3057179 |
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Synonyms: |
AI4aTg |
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Transgene:
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Tg(TcraAI4)1Dvs
Location:
unknown
Genetic Position: Chr1,
Syntenic
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Transgene
origin |
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Strain of Origin:
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NOD/ShiLt
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The rearranged Tcra transgene expressed in these mice is derived from the pancreatic beta cell-reactive CD8 T lymphocyte clone AI4. The transgene contains a Tcra-V8/Tcra-J cDNA segment. (J:93553)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
In conjunction with Rag1tm1Momtransgenic mice carrying both the alpha and beta AI4 TCR transgenes exhibit an accelerated development of insulin-dependent diabetes mellitus (IDDM). homozygous mice are viable and fertile
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| References |
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Original: |
J:93553
Graser RT et al.,
"Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions."
J Immunol 2000 Apr 1;164(7):3913-8
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All: |
16 reference(s)
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Analysis Tools
