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| Nomenclature |
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Symbol:
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Tg(PDGFB-APPSwInd)20Lms
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Name:
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transgene insertion 20, Lennart Mucke
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MGI ID: |
MGI:3057148 |
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Synonyms: |
APP/J20, APP Tg, hAPPJ20, J20, PDGF-APPSwInd, PDGF-hAPP695,751,770V171F, KM670/671NL |
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Transgene:
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Tg(PDGFB-APPSwInd)20Lms
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene expresses the mutant human amyloid protein precursor APPSwInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the human platelet derived growth factor, B polypeptide (PDGFB) promoter. Hemizygous transgenic mice express immunodetectable transgene product in cerebral neurons, with the highest level of expression occurring in the neocortex and hippocampus. ELISA analysis reveals approximate total amyloid beta peptides and 42 amino acid length amyloid beta peptides in neocortical and hippocampal tissue from transgenic mice. (J:62290)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This line is also called line J20.
Diffuse amyloid beta peptides deposition forms in the dendate gyrus and neocortex at 5 to 7 months of age. Amyloid deposition is progressive, with all transgenic mice exhibiting plaques by age 8 to 10 months.
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| References |
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Original: |
J:62290
Mucke L et al.,
"High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation."
J Neurosci 2000 Jun 1;20(11):4050-8
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All: |
77 reference(s)
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Analysis Tools
