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| Nomenclature |
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Symbol:
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Tg(MAPT)8cPdav
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Name:
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transgene insertion 8c, Peter Davies
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MGI ID: |
MGI:3057129 |
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Synonyms: |
8c, hTau |
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Transgene:
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Tg(MAPT)8cPdav
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Swiss Webster x (C57BL/6 x DBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains the coding sequence, intronic regions, and regulatory elements of the human microtubule-associated protein tau (MAPT) gene. (J:85952)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Mice that are homozygous for the Mapttm1(GFP)Klt allele and hemizygous for the transgene are viable and fertile. Although no endogenous mouse MAPT is detected, all six isoforms (including both 3R and 4R forms) of human MAPT are expressed. Hyperphosphorylated MAPT is detected in cell bodies and dendrites by 3 months of age. Paired helical filaments of aggregated insoluble MAPT can be isolated from brain tissue as early as 2 months of age.
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| References |
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Original: |
J:85952
Duff K et al.,
"Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes."
Neurobiol Dis 2000 Apr;7(2):87-98
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All: |
14 reference(s)
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Analysis Tools
