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| Nomenclature |
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Symbol:
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Tg(Igk-C/Igk-V125)1Jwt
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Name:
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transgene insertion 1, James W Thomas
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MGI ID: |
MGI:3057119 |
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Synonyms: |
VK125, VK125-Ck |
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Transgene:
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Tg(Igk-C/Igk-V125)1Jwt
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene encodes a light chain that, when co-expressed with a transgene encoding the heavy chain with the VDJ of mAB125, binds most mammalian insulins. The source of the immunoglobulin kappa chain VJ sequence in this transgene was the BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125 (from the American Type Culture Collection). (J:91865)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:91865
Hulbert C et al.,
"B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice."
J Immunol 2001 Nov 15;167(10):5535-8
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All: |
3 reference(s)
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Analysis Tools
