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| Nomenclature |
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Symbol:
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Tg(Igh-6/Igh-V281)3Jwt
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Name:
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transgene insertion 3, James W Thomas
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MGI ID: |
MGI:3056939 |
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Synonyms: |
281HC, H125.gl, VH281, VH281Tg |
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Transgene:
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Tg(Igh-6/Igh-V281)3Jwt
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The construct for Tg(Igh-6/Igh-V281)3Jwt has a germ line reversion encoding D at residue 49 (from G)and another encoding V (from E) at residue 56. The transgene encodes an IgMa constant region with a variable region nearly identical to that of the BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125, (from the American Type Culture Collection) but lacking the high affinity specificity for insulin. (J:91865)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:91865
Hulbert C et al.,
"B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice."
J Immunol 2001 Nov 15;167(10):5535-8
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All: |
2 reference(s)
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Analysis Tools
