|
|
| Nomenclature |
|
Symbol:
|
Tg(FCGR2A)11Mkz
|
|
Name:
|
transgene insertion 11, Steven E McKenzie
|
|
MGI ID: |
MGI:3056729 |
|
Synonyms: |
huFCGR2AR131 |
|
Transgene:
|
Tg(FCGR2A)11Mkz
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
(C57BL/6 x SJL)F2
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The transgene contains the human FCGR2A gene. The genomic clone used in the transgene encodes the R131 polymorphic form of human FcgRIIA, which binds the widest range of mouse IgG subclasses including mouse IgG1 and rat IgG2a as well. 10 copies of the transgene was estimated to have inserted into the genome. Transgenic mice express human FCGR2A on mouse platelets and macrophages at levels equivalent to that observed in human cells. (J:93244, J:136516)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
Phenotypic Similarity to Human Syndrome: heparin-induced thrombocytopenia (HIT) / Thrombocytopenia and Thrombosis (HITT) (J:72220)
|
| References |
|
Original: |
J:93244
McKenzie SE et al.,
"The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model."
J Immunol 1999 May 1;162(7):4311-8
|
|
All: |
10 reference(s)
|
|
Analysis Tools
